Ultrahigh-Molecular-Weight Polyethylene
Weihong Jin, Paul K. Chu, inEncyclopedia of Biomedical Engineering, 2019
UHMWPElayiri nepolyolefintare da maimaita naúrar - CH2CH2 -.UHMWPE mai darajar likitanci yana da dogayen sarƙoƙi tare da aadadin kwayoyin halittana 2 × 106-6 × 106 g mol-1 kuma shine aSemirystalline polymertare da saitin yankuna da aka ba da oda da aka saka cikin rashin lafiyaamorphous lokaci(Turell da Bellare, 2004).UHMWPE yana da ƙananan juzu'i, juriya mai girma, mai kyau tauri, babbatasiri ƙarfi, Babban juriya ga sinadarai masu lalata, kyakkyawan haɓakar halittu, da ƙarancin farashi.
An yi amfani da UHMWPE a asibitihadin gwiwa implantsfiye da shekaru 40, musamman a matsayin mai ɗaukar hoto a cikin jimlar maye gurbin hip da saka tibial a cikin maye gurbin gwiwa.A cikin 1962, an fara amfani da UHMWPE azaman abubuwan haɗin gwiwar acetabular kuma ya zama babbakayan aikia cikin jimlar maye gurbin hip tun 1970s.Koyaya, sawar UHMWPE a cikin hulɗa tare da ƙarin abubuwan da aka yi da ƙarfe ko yumbu babbar matsala ce a cikin ƙwararru a cikin 1980s musamman saboda ci gaba da daidaita sarƙoƙin polymer.Ƙarshen lalacewa na iya haifar da lalacewaosteolysisyana haifar da sassauta abubuwan da aka sanyawa da raunana tsarin kashi.
An sami babban ci gaba a cikin haɓakar UHMWPE mai haɗin kai sosai a ƙarshen 1990s.Ana aiwatar da haɗin kai na UHMWPE ta ko'ina ta hanyar radicalizing sarƙoƙi na gefe tare da radiation kamargamma ray,lantarki katako, ko sunadarai irin su peroxide don inganta juriya na lalacewa saboda raguwar motsi na sarƙoƙi na polymer bayan haɗin giciye (Lewis, 2001).Don ingantaoxidationjuriya, UHMWPE mai haɗin giciye ana kula da shi ta thermally.An yi nasarar amfani da UHMWPE mai haɗin kai sosai wajen ɗaukar kayagidajen abincikuma ya zama ma'auni a cikin jimlar maye gurbin hip.
Kafin a dasa su, gabaɗaya ana yin haifuwa ta hanyar iskar gamma a cikin iska.Gamma ray yana haifar da samuwar radicals ta hanyar tsinke sarka.Bayan iskancin gamma, radicals na kyauta na iya wanzuwa a cikin polymer kuma suna amsawa tare da nau'ikan O yayin ajiya ko a cikin vivo haifar da iskar oxygenation na UHMWPE (Premnath et al., 1996).Kodayake UHMWPE mai haɗin kai sosai ya haɓaka juriya, sauran kaddarorin kamar ductility,karaya tauri, juriyar gajiya, dakarfin jurewana iya yin sulhu ta hanyar iska mai guba (Lewis, 2001; Premnath et al., 1996).
Hanyoyin da ba a haɗa su ba kamar haifuwa ta amfani da iskar ethylene oxide kogas plasmafitowa, kuma an gudanar da wasu jiyya na ƙarfafawa bayan haɗin kai don kawar da tasirin da aka ambata a baya (Kurtz et al., 1999).A antioxidantbitamin EHakanan an haɗa shi cikin UHMWPE mai haɗin kai don murkushe iskar oxygen ta hanyar amsawa tare da radicals kyauta (Bracco da Oral, 2011).
Har yanzu babu tarihin asibiti a cikin abubuwan maye gurbin haɗin gwiwa ko da yake bitamin E yana nuna aminci da daidaituwa.Don haka, hanyoyin da za a haɓaka juriya na lalacewa ba tare da lalata duk wasu mahimman kaddarorin UHMWPE da aikace-aikacen asibiti na dogon lokaci ana son UHMWPE a cikinaikace-aikacen orthopedic.
Lokacin aikawa: Juni-26-2023
