I-Ultrahigh-Molecular-Weight Polyethylene
Weihong Jin, Paul K. Chu, inEncyclopedia of Biomedical Engineering, 2019
UHMWPEiwumugqai-polyolefinngeyunithi ephindayo engu-− CH2CH2 −.I-UHMWPE yebanga lezokwelapha inamaketango amade aneisisindo samangqamuzanaka-2 × 106–6 × 106 g mol− 1 futhi iyi-i-semicrystalline polymerngesethi yezifunda ezi-odwe ezishumekwe endaweni engalungileisigaba se-amorphous(Turell noBellare, 2004).I-UHMWPE inokungqubuzana okuphansi, ukumelana nokugqoka okuphezulu, ukuqina okuhle, okuphezuluamandla omthelela, ukumelana okuphezulu kumakhemikhali abolayo, i-biocompatibility enhle kakhulu, nezindleko eziphansi.
I-UHMWPE isetshenziswe emtholampilookuhlangene izimilaiminyaka engaphezu kwengu-40, ikakhulukazi njenge-articular liner ekufakweni okuphelele kwe-hip kanye nokufakwa kwe-tibial ekushintsheni okuphelele kwamadolo.Ngo-1962, i-UHMWPE yaqala ukusetshenziswa njengezingxenye ze-acetabular futhi isiyiyona ehamba phambili.izinto zokuthwalaekubuyiselweni kwe-hip okuphelele kusukela ngawo-1970.Kodwa-ke, ukuguga kwe-UHMWPE lapho kuthintana nezingxenye eziqinile ezenziwe ngezinsimbi noma izitsha zobumba kwakuyinkinga enkulu kudokotela wamathambo ngeminyaka yawo-1980 ikakhulukazi ngenxa yokuhlenga kabusha okuqhubekayo kwamaketanga e-polymer.Izingubo zokugqoka zingase zibangelei-osteolysisokuholela ekuxegisweni kwezimila kanye nokuba buthaka kwesakhiwo samathambo.
Kube khona impumelelo enkulu ekuthuthukisweni kwe-UHMWPE exhumene kakhulu ngasekupheleni kwawo-1990.Cross-linking of UHMWPE lusetshenziswa kabanzi by radicalizing amaketanga aseceleni ngemisebe efanai-gamma ray,insimbi ye-electron, noma amakhemikhali afana ne-peroxide ukuze athuthukise ukumelana nokugqokwa ngenxa yokuncipha kokuhamba kwamaketanga e-polymer ngemva kokuxhumanisa (Lewis, 2001).Ukuthuthukisa ii-oxidationukumelana, i-UHMWPE exhunywe ngokuphambanayo iphathwa ngokushisa.I-UHMWPE exhunywe kakhulu isetshenziswe ngempumelelo ekuthwaleni umthwaloamalungafuthi iba indinganiso ekubuyiselweni kwe-hip isiyonke.
Ngaphambi kokufakelwa, izimila ze-orthopedic zivame ukuvalwa inzalo nge-gamma irradiation emoyeni ozungezile.I-Gamma ray yenza ukwakheka kwama-radicals mahhala ngokuqhekeka kweketango.Ngemuva kwe-gamma irradiation, ama-radicals wamahhala asengaba khona ku-polymer futhi asabele ngezinhlobo ze-O ezitholakalayo ngesikhathi sokugcinwa noma ku-vivo abangele i-oxidation eyingozi ye-UHMWPE (Premnath et al., 1996).Yize i-UHMWPE exhumene kakhulu ithuthukise ukumelana nokugqokwa, ezinye izakhiwo ezifana ne-ductility,ukuqina kwe-fracture, ukumelana nokukhathala, futhiamandla aqinileingase ibe sengozini nge-gamma irradiation (Lewis, 2001; Premnath et al., 1996).
Izindlela ze-Nonionizing ezifana nokuvala inzalo kusetshenziswa i-ethylene oxide gas nomaigesi ye-plasmakuvela, futhi okunye ukwelashwa kokuzinzisa kwenziwe ngemuva kokuxhumanisa ukuze kuqedwe ithonya elibi okukhulunywe ngalo ekuqaleni (Kurtz et al., 1999).I-antioxidantvitamin Eiphinde ifakwe ku-UHMWPE exhumene kakhulu ukuze icindezele i-oxidation ngokusabela ngama-radicals wamahhala (Bracco and Oral, 2011).
Awukabi khona umlando womtholampilo ezingxenyeni ezishintshayo ezihlanganyelwe nakuba uvithamini E ebonisa ukuphepha nokuvumelana kwezinto eziphilayo.Ngakho-ke, izindlela zokuthuthukisa ukumelana nokugqokwa ngaphandle kokuphazamisa noma yiziphi ezinye izakhiwo ezibalulekile ze-UHMWPE kanye nesicelo somtholampilo sesikhathi eside sifiseleka ku-UHMWPEizicelo zamathambo.
Isikhathi sokuthumela: Jun-26-2023
