Ultrahigh-Molecular-Weight Polyethylene
Weihong Jin, Paul K. Chu, kaEncyclopedia of Biomedical Engineering, 2019
UHMWPEke linearpolyolefineka yuniti e pheta-phetoang ea − CH2CH2 −.Medical-grade UHMWPE e na le liketane tse telele tse nang leboima ba molek'huleea 2 × 106–6 × 106 g mol− 1 mme kepolymer ea semicrystallinee nang le sehlopha sa libaka tse hlophisitsoeng tse kentsoeng sebakeng se sa tsitsangmokhahlelo oa amorphous(Turell le Bellare, 2004).UHMWPE e na le likhohlano tse tlase, khanyetso e phahameng ea ho roala, boima bo botle, bo phahamengmatla a tshusumetso, khanyetso e phahameng ea lik'hemik'hale tse senyang, biocompatibility e babatsehang, le litšenyehelo tse tlaase.
UHMWPE e se e sebelisitsoe tleliniking hokopanetsoe li-implantbakeng sa lilemo tse fetang 40, haholo-holo e le li-articular liner ka kakaretso ea letheka le ho kenya tibial ka ho fetola lengole.Ka 1962, UHMWPE e ile ea sebelisoa ka lekhetlo la pele e le metsoako ea acetabular 'me e fetohile eona e ka sehloohong.ho beha thepaka kakaretso ea li-hip replacements ho tloha ka bo-1970.Leha ho le joalo, ho roaloa ha UHMWPE ha ho kopane le likarolo tse thata tse entsoeng ka tšepe kapa lirafshoa e ne e le bothata bo boholo ho lingaka tsa masapo lilemong tsa bo-1980 haholo-holo ka lebaka la ho tsosolosoa ho tsoelang pele ha liketane tsa polymer.Mafura a ka 'nang a hlahaosteolysisho lebisa ho ho hlephisa hoa ho kenngoeng le ho fokolisa sebopeho sa masapo.
Ho bile le katleho e kholo ho nts'etsopele ea UHMWPE e amanang haholo bofelong ba lilemo tsa bo-1990.Cross-linking ea UHMWPE ke ho pharaletseng kenngwa tshebetsong ka radicalizing mahlakoreng a liketane ka mahlaseli a kangmahlaseli a gamma,lebone la elektronike, kapa lik'hemik'hale tse kang peroxide ho ntlafatsa ho hanyetsa ho apara ka lebaka la ho fokotseha ho tsamaeang ha liketane tsa polymer ka mor'a ho kopanya (Lewis, 2001).Ho ntlafatsa boemo baoxidationkhanyetso, UHMWPE e amanang le sefapano e alafshoa ka mocheso.UHMWPE e hokahaneng haholo e 'nile ea sebelisoa ka katleho ho jarang meroalomanonyeletso'me e fetoha maemo a tloaelehileng a ho fetola letheka.
Pele ho kenngoa, li-implants tsa masapo hangata li hloekisoa ka mahlaseli a gamma moeeng o tikolohong.Gamma ray e etsa hore ho be le li-radicals tsa mahala ka ho phunyeha ha ketane.Ka mor'a mahlaseli a gamma, li-radicals tsa mahala li ntse li ka 'na tsa e-ba teng ka har'a polymer 'me li sebetsana le mefuta ea O e teng nakong ea polokelo kapa ka vivo e baka oxidation e kotsi ea UHMWPE (Premnath et al., 1996).Leha UHMWPE e hokahaneng haholo e matlafalitse khanyetso ea moaparo, thepa e meng joalo ka ductility,ho qhetsoha ho thata, ho hanyetsa mokhathala, lematla a tšepee ka 'na ea sekisetsoa ke gamma irradiation (Lewis, 2001; Premnath et al., 1996).
Mekhoa e sa tsitsang e kang sterilization e sebelisang ethylene oxide gas kapaplasma ea khasehlaha, 'me phekolo e' ngoe ea botsitso e boetse e entsoe ka mor'a ho hokahanya ho felisa tšusumetso e mpe e boletsoeng pejana (Kurtz et al., 1999).Antioxidantvithamine Ee boetse e kenyelelitsoe ho UHMWPE e hokahantsoeng ho thibela oxidation ka ho arabela ka li-radicals tsa mahala (Bracco le Oral, 2011).
Ho ntse ho se na nalane ea bongaka likarolong tse kopaneng tsa phetisetso le hoja vithamine E e bonts'a polokeho le biocompatibility.Ka hona, mekhoa ea ho ntlafatsa khanyetso ea ho roala ntle le ho senya thepa e 'ngoe ea bohlokoa ea UHMWPE le ts'ebeliso ea nako e telele ea bongaka e lakatseha bakeng sa UHMWPElits'ebetso tsa masapo.
Nako ea poso: Jun-26-2023
