Ultrahigh-Molecular-Weight Polyethylene
Weihong Jin, uPaul K. Chu, kwiI-Encyclopedia yoBunjineli beBiomedical, 2019
UHMWPEngumgcaipololefinkunye neyunithi ephinda-phindayo - CH2CH2 -.Medical-grade UHMWPE inamatyathanga amade kunyeubunzima bemolekyuliye-2 × 106–6 × 106 g mol− 1 kwayei-semicrystalline polymerkunye neseti yemimandla ecwangcisiweyo efakwe kwindawo ephazamisekileyoisigaba se-amorphous(Turell noBellare, 2004).I-UHMWPE inokruthakruthwano oluphantsi, ukumelana nokunxiba okuphezulu, ukuqina okuhle, phezuluamandla empembelelo, ukuxhathisa okuphezulu kwiikhemikhali ezonakalisayo, i-biocompatibility egqwesileyo, kunye neendleko eziphantsi.
UHMWPE isetyenziswe eklinikhi kwingokubambisana ukufakelwangaphezu kweminyaka engama-40, ngokukodwa njenge-articular liner ekutshintsheni i-hip epheleleyo kunye nokufakwa kwe-tibial ekutshintsheni idolo elipheleleyo.Ngo-1962, i-UHMWPE yaqala ukusetyenziswa njengamacandelo e-acetabular kwaye iye yaba yeyona ibalaseleyo.izinto zokuthwalangokutshintshwa kwenyonga ngokupheleleyo ukusukela ngoo-1970.Nangona kunjalo, ukunxitywa kwe-UHMWPE ekudibaneni nezixhobo eziqinileyo ezenziwe ngesinyithi okanye iiseramikhi yayiyingxaki enkulu kwi-orthopedics kwiminyaka yoo-1980 ngenxa yohlengahlengiso oluqhubekayo lwamakhonkco e-polymer.Ubuncwane bokugqoka bunokubangelai-osteolysisokukhokelela ekukhululweni kokufakelwa kunye nokuncipha kwesakhiwo samathambo.
Kwabakho impumelelo enkulu kuphuhliso lwe-UHMWPE enxibelelene kakhulu ekupheleni kweminyaka yoo-1990.Cross-linking of UHMWPE luphunyezwe ngokubanzi ngokutshintsha amatyathanga macala kunye radiation ezifanaimitha yegama,Umqa we-electron, okanye iikhemikhali ezifana ne-peroxide ukuphucula ukunyanzeliswa kokugqoka ngenxa yokunciphisa ukuhamba kwamaketanga e-polymer emva kokudibanisa (Lewis, 2001).Ukuphucula ii-oxidationukumelana, i-UHMWPE edityaniswe ngomnqamlezo iphathwa ngokushushu.I-UHMWPE edityaniswe kakhulu isetyenziswe ngempumelelo ekuthwaleni umthwaloamalungukwaye iba ngumgangatho wokutshintshwa kwe-hip epheleleyo.
Phambi kokufakelwa, ukufakelwa kwe-orthopedic kusenziwa inzala ye-gamma kumoya ojikelezayo.I-Gamma ray ibangela ukwakheka kweeradicals zasimahla ngokuqhekeka kwekhonkco.Emva kwe-gamma irradiation, i-radicals yamahhala isenokubakho kwi-polymer kwaye iphendule kunye neentlobo ze-O ezikhoyo ngexesha lokugcinwa okanye kwi-vivo zenza i-oxidation eyingozi ye-UHMWPE (Premnath et al., 1996).Nangona i-UHMWPE eqhagamshelwe kakhulu iye yaphucula ukuxhathisa ukunxiba, ezinye iipropathi ezinje nge-ductility,ukwaphuka kokuqina, ukuxhathisa ukukhathala, kunyetensile strengthinokuthi ibekwe esichengeni yi-gamma irradiation (Lewis, 2001; Premnath et al., 1996).
iindlela Nonionizing ezifana inzala usebenzisa ethylene oxide igesi okanyeiplasma yegesiukuvela, kwaye unyango oluthile lokuzinzisa luye lwaqhutywa emva kokudibanisa ukuphelisa impembelelo echasayo ekhankanywe ngaphambili (Kurtz et al., 1999).I-antioxidantivithamin Eiphinde ifakwe kwi-UHMWPE edibeneyo yokuxinzelela i-oxidation ngokusabela nge-radicals yamahhala (i-Bracco kunye ne-Oral, i-2011).
Akukabikho imbali yeklinikhi kumacandelo okutshintshwa ngokudibeneyo nangona i-vitamin E ibonisa ukhuseleko kunye ne-biocompatibility.Ke ngoko, iindlela zokuphucula ukuxhathisa kokunxiba ngaphandle kokuphazamisa naziphi na ezinye iipropathi ezibalulekileyo ze-UHMWPE kunye nesicelo seklinikhi yexesha elide ziyafuneka kwi-UHMWPEizicelo zamathambo.
Ixesha lokuposa: Jun-26-2023
