Ultrahigh-Molecular- Nyhav Polyethylene
Weihong Jin, Paul K. Chu, inEncyclopedia ntawm Biomedical Engineering, xyoo 2019
UHMWPEyog linearpolyolefinnrog ib chav tsev rov ua dua ntawm − CH2CH2 −.Kev kho mob-qib UHMWPE muaj ntev chains nrog amolecular lojntawm 2 × 106–6 × 106 g mol− 1 thiab yog asemicrystalline polymernrog ib pawg ntawm cov cheeb tsam txiav txim embedded nyob rau hauv ib qho kev tsis sib haum xeebamorphous theem(Turell thiab Bellare, 2004).UHMWPE muaj kev sib txhuam tsawg, hnav tsis kam, zoo toughness, siabcuam tshuam lub zog, siab tsis kam rau cov tshuaj corrosive, zoo heev biocompatibility, thiab tus nqi qis.
UHMWPE tau siv hauv kev kho mob hauvsib koom cograu ntau tshaj 40 xyoo, tshwj xeeb tshaj yog raws li ib tug articular liner nyob rau hauv tag nrho lub duav hloov thiab tibial ntxig rau tag nrho lub hauv caug hloov.Xyoo 1962, UHMWPE yog thawj zaug siv los ua acetabular Cheebtsam thiab tau dhau los ua qhov tseem ceeb.bearing cov ntaub ntawvhauv tag nrho lub duav hloov txij li xyoo 1970s.Txawm li cas los xij, kev hnav ntawm UHMWPE nyob rau hauv kev sib cuag nrog cov khoom nyuaj ua los ntawm cov hlau lossis ceramics yog ib qho teeb meem loj hauv orthopedics hauv xyoo 1980s feem ntau yog vim muaj kev hloov pauv ntawm cov saw hlau txuas ntxiv.Cov khib nyiab hnav tuaj yeem ua rauosteolysisua rau loosening ntawm implants thiab tsis muaj zog ntawm cov pob txha qauv.
Muaj kev ua txhaum loj hauv kev txhim kho ntawm kev sib txuas ntawm UHMWPE nyob rau xyoo 1990s.Hla-txuas ntawm UHMWPE yog dav siv los ntawm radicalizing sab chains nrog hluav taws xob xws ligamma ray,electron nqaj, los yog tshuaj xws li peroxide los txhim kho qhov hnav tsis kam vim qhov txo qis ntawm cov khoom siv polymer tom qab sib txuas (Lewis, 2001).Txhim kho covoxidationtsis kam, tus ntoo khaub lig-txuas UHMWPE yog thermally kho.Highly cross-linked UHMWPE tau ntse siv nyob rau hauv load-bearingpob qij txhathiab dhau los ua tus qauv hauv tag nrho lub duav hloov.
Ua ntej cog, orthopedic implants feem ntau sterilized los ntawm gamma irradiation nyob rau hauv ambient huab cua.Gamma ray induces tsim cov dawb radicals los ntawm saw cleavage.Tom qab gamma irradiation, dawb radicals tseem yuav muaj nyob rau hauv lub polymer thiab hnov nrog O hom thaum lub sij hawm cia los yog nyob rau hauv vivo induce detrimental oxidation ntawm UHMWPE (Premnath li al., 1996).Txawm hais tias muaj kev sib txuas ntau ntawm UHMWPE tau txhim kho kev hnav tsis kam, lwm yam khoom xws li ductility,tawg toughness, qaug zog tiv taus, thiabtensile zogtej zaum yuav raug cuam tshuam los ntawm gamma irradiation (Lewis, 2001; Premnath li al., 1996).
Nonionizing txoj kev xws li sterilization siv ethylene oxide roj los yoggas plasmatshwm sim, thiab qee qhov kev kho kom ruaj khov kuj tau ua tom qab kev sib txuas los tshem tawm cov kev cuam tshuam uas tau hais ua ntej (Kurtz li al., 1999).Cov tshuaj antioxidantvitamin Ekuj tseem tau muab tso rau hauv kev sib txuas ntawm UHMWPE txhawm rau txhawm rau oxidation los ntawm kev ua haujlwm nrog cov dawb radicals (Bracco thiab Oral, 2011).
Tseem tsis muaj keeb kwm kho mob hauv kev sib koom ua ke hloov khoom txawm tias vitamin E qhia txog kev nyab xeeb thiab biocompatibility.Yog li ntawd, cov hau kev los txhim kho cov hnav tsis kam tsis muaj kev cuam tshuam lwm yam tseem ceeb ntawm UHMWPE thiab daim ntawv thov kev kho mob mus sij hawm ntev yog xav tau rau UHMWPE hauvkev siv orthopedic.
Post lub sij hawm: Jun-26-2023
